Wales will face Mexico in a friendly in California on May 28.
The Football Association of Wales announced the fixture – to be played at the Rose Bowl Stadium in Pasadena – on Thursday night.
“This will be a fantastic opportunity for us to prove ourselves against a side that’s heading to the World Cup later in the summer,” manager Ryan Giggs said.
“The Rose Bowl is a magnificent stadium and it will be a great experience for all the players.”
Giggs, appointed as Chris Coleman’s replacement in January, takes charge of his first game against China on March 22.
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